A commensal strain of Staphylococcus epidermidis protects against skin neoplasia

We report the discovery that strains of Staphylococcus epidermidis produce 6-N-hydroxyaminopurine (6-HAP), a molecule that inhibits DNA polymerase activity. In culture, 6-HAP selectively inhibited proliferation of tumor lines but did not inhibit primary keratinocytes. Resistance to 6-HAP was associa...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Nakatsuji, Teruaki, Chen, Tiffany H., Butcher, Anna M., Trzoss, Lynnie L., Nam, Sang-Jip, Shirakawa, Karina T., Zhou, Wei, Oh, Julia, Otto, Michael, Fenical, William, Gallo, Richard L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5834004/
https://ncbi.nlm.nih.gov/pubmed/29507878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aao4502
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