The responsively decreased PKM2 facilitates the survival of pancreatic cancer cells in hypoglucose

Cancer cells predominantly produce energy at a high rate of glycolysis even in aerobic environment. It is termed as Warburg effect and is necessary for the tumorigenesis. Studies showed pyruvate kinase M2 (PKM2), a key regulator of the Warburg effect, is overexpressed and involved in numerous cancer...

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Bibliografske podrobnosti
izdano v:Cell Death Dis
Main Authors: Li, Xiang, Deng, Shichang, Liu, Mingliang, Jin, Yan, Zhu, Shuai, Deng, Shijiang, Chen, Jingyuan, He, Chi, Qin, Qi, Wang, Chunyou, Zhao, Gang
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833844/
https://ncbi.nlm.nih.gov/pubmed/29374159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0158-5
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