Pharmacological activation of autophagy favors the clearing of intracellular aggregates of misfolded prion protein peptide to prevent neuronal death

According to the “gain-of-toxicity mechanism”, neuronal loss during cerebral proteinopathies is caused by accumulation of aggregation-prone conformers of misfolded cellular proteins, although it is still debated which aggregation state actually corresponds to the neurotoxic entity. Autophagy, origin...

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Publicat a:Cell Death Dis
Autors principals: Thellung, Stefano, Scoti, Beatrice, Corsaro, Alessandro, Villa, Valentina, Nizzari, Mario, Gagliani, Maria Cristina, Porcile, Carola, Russo, Claudio, Pagano, Aldo, Tacchetti, Carlo, Cortese, Katia, Florio, Tullio
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833808/
https://ncbi.nlm.nih.gov/pubmed/29416016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0252-8
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