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BRD4 regulates cellular senescence in gastric cancer cells via E2F/miR-106b/p21 axis

Small molecules targeting bromodomains of BET proteins possess strong anti-tumor activities and have emerged as potential therapeutics for cancer. However, the underlying mechanisms for the anti-proliferative activity of these inhibitors are still not fully characterized. In this study, we demonstra...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Dong, Xingchen, Hu, Xiangming, Chen, Jinjing, Hu, Dan, Chen, Lin-Feng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833665/
https://ncbi.nlm.nih.gov/pubmed/29434197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0181-6
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