Granzyme B deficiency promotes osteoblastic differentiation and calcification of vascular smooth muscle cells in hypoxic pulmonary hypertension

Calcification is a major risk factor for vascular integrity. This pathological symptom and the underlying mechanisms in hypoxic pulmonary artery hypertension remain elusive. Here we report that pulmonary vascular medial calcification is elevated in pulmonary artery hypertension models as a result of...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Mao, Min, Zhang, Min, Ge, Anqi, Ge, Xin, Gu, Rui, Zhang, Chen, Fu, Yao, Gao, Jiayin, Wang, Xiaoying, Liu, Yang, Zhu, Daling
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833422/
https://ncbi.nlm.nih.gov/pubmed/29445095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0315-5
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