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SMAD4 feedback regulates the canonical TGF-β signaling pathway to control granulosa cell apoptosis

Canonical TGF-β signals are transduced from the cell surface to the cytoplasm, and then translocated into the nucleus, a process that involves ligands (TGF-β1), receptors (TGFBR2/1), receptor-activated SMADs (SMAD2/3), and the common SMAD (SMAD4). Here we provide evidence that SMAD4, a core componen...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Du, Xing, Pan, Zengxiang, Li, Qiqi, Liu, Honglin, Li, Qifa
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833407/
https://ncbi.nlm.nih.gov/pubmed/29396446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0205-2
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