Nrf2 antioxidant pathway suppresses Numb-mediated epithelial–mesenchymal transition during pulmonary fibrosis

Epithelial mesenchymal transition (EMT) is a key progression that promotes pulmonary fibrosis (PF). Numb, a phosphotyrosine-binding domain (PTB) protein, is implicated with EMT. Nuclear factor erythroid 2-related factor2 (Nrf2) and its downstream proteins heme oxygenase-1 (HO-1) and NAD(P)H: quinone...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Zhang, Zhihui, Qu, Jiao, Zheng, Cheng, Zhang, Panpan, Zhou, Wencheng, Cui, Wenhui, Mo, Xiaoting, Li, Liucheng, Xu, Liang, Gao, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833372/
https://ncbi.nlm.nih.gov/pubmed/29362432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0198-x
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