Sensitisation to mitoxantrone-induced apoptosis by the oncolytic adenovirus Ad∆∆ through Bcl-2-dependent attenuation of autophagy

Anti-apoptotic Bcl-2 is frequently activated in human malignant cells to promote cell survival and inhibit cell death. Replication-selective oncolytic adenoviruses deleted in the functional Bcl-2 homologue E1B19K potently synergise with apoptosis-inducing chemotherapeutic drugs, including mitoxantro...

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Vydáno v:Oncogenesis
Hlavní autoři: Aguirre-Hernández, Carmen, Maya-Pineda, Héctor, Millán, Julia San, Man, Y. K. Stella, Lu, Yong-Jie, Halldén, Gunnel
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833340/
https://ncbi.nlm.nih.gov/pubmed/29362360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-017-0020-8
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