Eplerenone attenuates pathological pulmonary vascular rather than right ventricular remodeling in pulmonary arterial hypertension

BACKGROUND: Aldosterone is a mineralocorticoid hormone critically involved in arterial blood pressure regulation. Although pharmacological aldosterone antagonism reduces mortality and morbidity among patients with severe left-sided heart failure, the contribution of aldosterone to the pathobiology o...

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Vydáno v:BMC Pulm Med
Hlavní autoři: Boehm, Mario, Arnold, Nadine, Braithwaite, Adam, Pickworth, Josephine, Lu, Changwu, Novoyatleva, Tatyana, Kiely, David G., Grimminger, Friedrich, Ghofrani, Hossein A., Weissmann, Norbert, Seeger, Werner, Lawrie, Allan, Schermuly, Ralph T., Kojonazarov, Baktybek
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833097/
https://ncbi.nlm.nih.gov/pubmed/29499691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12890-018-0604-x
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