A pilot study of a non-invasive oral nitrate stable isotopic method suggests that arginine and citrulline supplementation increases whole-body NO production in Tanzanian children with sickle cell disease

BACKGROUND: Low bioavailability of nitric oxide (NO) is implicated in the pathophysiology of sickle cell disease (SCD). We designed a nested pilot study to be conducted within a clinical trial testing the effects of a daily ready-to-use supplementary food (RUSF) fortified with arginine (Arg) and cit...

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Bibliografiske detaljer
Udgivet i:Nitric Oxide
Main Authors: Marealle, Alphonce I., Siervo, Mario, Wassel, Sara, Bluck, Les, Prentice, Andrew M., Minzi, Omary, Sasi, Philip, Kamuhabwa, Appolinary, Soka, Deogratias, Makani, Julie, Cox, Sharon E.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832986/
https://ncbi.nlm.nih.gov/pubmed/29305240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.niox.2017.12.009
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