The combined effect of Pdx1 overexpression and Shh manipulation on the function of insulin‐producing cells derived from adipose‐tissue stem cells

Pancreatic and duodenal homeobox 1 (Pdx1) and Sonic hedgehog (Shh) are the key regulators of beta‐cell function. In vitro experiments have shown that there is significant cooperation between Pdx1 and Shh with regard to the production and maintenance of insulin‐producing cells (IPCs). In this study,...

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Bibliographic Details
Published in:FEBS Open Bio
Main Authors: Hashemi Tabar, Mahmoud, Tabandeh, Mohammad Reza, Moghimipour, Eskandar, Dayer, Dian, Ghadiri, Ata A., Allah Bakhshi, Elham, Orazizadeh, Mahmoud, Ghafari, Mohammad Ali
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2018
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832980/
https://ncbi.nlm.nih.gov/pubmed/29511614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12378
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