An Elastomeric Polymer Matrix, PEUU-Tac, Delivers Bioactive Tacrolimus Transdurally to the CNS in Rat

Central nervous system (CNS) neurons fail to regrow injured axons, often resulting in permanently lost neurologic function. Tacrolimus is an FDA-approved immunosuppressive drug with known neuroprotective and neuroregenerative properties in the CNS. However, tacrolimus is typically administered syste...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: van der Merwe, Yolandi, Faust, Anne E., Conner, Ian, Gu, Xinzhu, Feturi, Firuz, Zhao, Wenchen, Leonard, Bianca, Roy, Souvik, Gorantla, Vijay S., Venkataramanan, Raman, Washington, Kia M., Wagner, William R., Steketee, Michael B.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832622/
https://ncbi.nlm.nih.gov/pubmed/29208469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2017.11.017
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