An Elastomeric Polymer Matrix, PEUU-Tac, Delivers Bioactive Tacrolimus Transdurally to the CNS in Rat

Central nervous system (CNS) neurons fail to regrow injured axons, often resulting in permanently lost neurologic function. Tacrolimus is an FDA-approved immunosuppressive drug with known neuroprotective and neuroregenerative properties in the CNS. However, tacrolimus is typically administered syste...

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Bibliografiske detaljer
Udgivet i:EBioMedicine
Main Authors: van der Merwe, Yolandi, Faust, Anne E., Conner, Ian, Gu, Xinzhu, Feturi, Firuz, Zhao, Wenchen, Leonard, Bianca, Roy, Souvik, Gorantla, Vijay S., Venkataramanan, Raman, Washington, Kia M., Wagner, William R., Steketee, Michael B.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832622/
https://ncbi.nlm.nih.gov/pubmed/29208469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2017.11.017
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