Murine cytomegalovirus degrades MHC class II to colonize the salivary glands

Cytomegaloviruses (CMVs) persistently and systemically infect the myeloid cells of immunocompetent hosts. Persistence implies immune evasion, and CMVs evade CD8(+) T cells by inhibiting MHC class I-restricted antigen presentation. Myeloid cells can also interact with CD4(+) T cells via MHC class II...

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Udgivet i:PLoS Pathog
Main Authors: Yunis, Joseph, Farrell, Helen E., Bruce, Kimberley, Lawler, Clara, Sidenius, Stine, Wyer, Orry, Davis-Poynter, Nicholas, Stevenson, Philip G.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5831752/
https://ncbi.nlm.nih.gov/pubmed/29447285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006905
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