Intranasally Delivered Wnt3a Improves Functional Recovery after Traumatic Brain Injury by Modulating Autophagic, Apoptotic, and Regenerative Pathways in the Mouse Brain

Traumatic brain injury (TBI) is a prevalent disorder, but no effective therapies currently exist. An underlying pathophysiology of TBI includes the pathological elevation of autophagy. β-Catenin, a downstream mediator of the canonical Wnt pathway, is a repressor of autophagy. The Wnt/β-catenin pathw...

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Bibliografiske detaljer
Udgivet i:J Neurotrauma
Main Authors: Zhang, James Ya, Lee, Jin Hwan, Gu, Xiaohuan, Wei, Zheng Zachory, Harris, Mallory Jessica, Yu, Shan Ping, Wei, Ling
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc. 2018
Fag:
Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5831263/
https://ncbi.nlm.nih.gov/pubmed/29108471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/neu.2016.4871
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