HCN4 pacemaker channels attenuate the parasympathetic response and stabilize the spontaneous firing of the sinoatrial node

KEY POINTS: The contribution of HCN4 pacemaker channels in the autonomic regulation of the sino‐atrial node (SAN) has been a matter of debate. The transgenic overexpression of HCN4 did not induce tachycardia, but reduced heart rate variability, while the conditional knockdown of HCN4 gave rise to si...

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Udgivet i:J Physiol
Main Authors: Kozasa, Yuko, Nakashima, Noriyuki, Ito, Masayuki, Ishikawa, Taisuke, Kimoto, Hiroki, Ushijima, Kazuo, Makita, Naomasa, Takano, Makoto
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
Fag:
Cardiovascular
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5830425/
https://ncbi.nlm.nih.gov/pubmed/29315578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP275303
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