miR-144/451 represses the LKB1/AMPK/mTOR pathway to promote red cell precursor survival during recovery from acute anemia

The microRNAs miR-144 and -451 are encoded by a bicistronic gene that is strongly induced during red blood cell formation (erythropoiesis). Ablation of the miR-144/451 gene in mice causes mild anemia under baseline conditions. Here we show that miR-144/451(−/−) erythroblasts exhibit increased apopto...

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Pubblicato in:Haematologica
Autori principali: Fang, Xiao, Shen, Feiyang, Lechauve, Christophe, Xu, Peng, Zhao, Guowei, Itkow, Jacobi, Wu, Fan, Hou, Yaying, Wu, Xiaohui, Yu, Lingling, Xiu, Huiqing, Wang, Mengli, Zhang, Ruiling, Wang, Fangfang, Zhang, Yanqing, Wang, Daxin, Weiss, Mitchell J., Yu, Duonan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Ferrata Storti Foundation 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5830375/
https://ncbi.nlm.nih.gov/pubmed/29269522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2017.177394
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