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Myocardial polyploidization creates a barrier to heart regeneration in zebrafish

Correlative evidence suggests that polyploidization of heart muscle, which occurs naturally in post-natal mammals, creates a barrier to heart regeneration. Here, we move beyond a correlation by demonstrating that experimental polyploidization of zebrafish cardiomyocytes is sufficient to suppress the...

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Detalhes bibliográficos
Publicado no:Dev Cell
Main Authors: González-Rosa, Juan Manuel, Sharpe, Michka, Field, Dorothy, Soonpaa, Mark H., Field, Loren J., Burns, Caroline E., Burns, C. Geoffrey
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5830170/
https://ncbi.nlm.nih.gov/pubmed/29486195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2018.01.021
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