Transient transcriptional silencing alters the cell cycle to promote germline stem cell differentiation in Drosophila

Transcriptional silencing is a conserved process used by embryonic germ cells to repress somatic fate and maintain totipotency and immortality. In Drosophila, this transcriptional silencing is mediated by polar granule component (pgc). Here, we show that in the adult ovary, pgc is required for timel...

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Gepubliceerd in:Dev Biol
Hoofdauteurs: Flora, Pooja, Schowalter, Sean, Wong-Deyrup, SiuWah, DeGennaro, Matthew, Nasrallah, Mohamad Ali, Rangan, Prashanth
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5830152/
https://ncbi.nlm.nih.gov/pubmed/29198563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2017.11.014
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