Geranylgeranylacetone attenuates fibrogenic activity and induces apoptosis in cultured human hepatic stellate cells and reduces liver fibrosis in carbon tetrachloride-treated mice

BACKGROUND: Geranylgeranylacetone (GGA), an anti-ulcer drug widely used in Japan, has attracted interest because of its various therapeutic effects. Therefore, we investigated the effects of GGA on human hepatic stellate cells (HSCs) in vitro and in a mouse model of liver fibrosis. METHODS: LX2, an...

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發表在:BMC Gastroenterol
Main Authors: Senoo, Takemasa, Sasaki, Ryu, Akazawa, Yuko, Ichikawa, Tatsuki, Miuma, Satoshi, Miyaaki, Hisamitsu, Taura, Naota, Nakao, Kazuhiko
格式: Artigo
語言:Inglês
出版: BioMed Central 2018
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5830074/
https://ncbi.nlm.nih.gov/pubmed/29486718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12876-018-0761-7
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