mGluR5 antagonism inhibits cocaine reinforcement and relapse by elevation of extracellular glutamate in the nucleus accumbens via a CB1 receptor mechanism

Metabotropic glutamate receptor 5 (mGluR5) antagonism inhibits cocaine self-administration and reinstatement of drug-seeking behavior. However, the cellular and molecular mechanisms underlying this action are poorly understood. Here we report a presynaptic glutamate/cannabinoid mechanism that may un...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Li, Xia, Peng, Xiao-Qing, Jordan, Chloe J., Li, Jie, Bi, Guo-Hua, He, Yi, Yang, Hong-Ju, Zhang, Hai-Ying, Gardner, Eliot L., Xi, Zheng-Xiong
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5829076/
https://ncbi.nlm.nih.gov/pubmed/29487381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-22087-1
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki