Influenza A viruses alter the stability and antiviral contribution of host E3-ubiquitin ligase Mdm2 during the time-course of infection

The interplay between influenza A viruses (IAV) and the p53 pathway has been reported in several studies, highlighting the antiviral contribution of p53. Here, we investigated the impact of IAV on the E3-ubiquitin ligase Mdm2, a major regulator of p53, and observed that IAV targets Mdm2, notably via...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Pizzorno, Andrés, Dubois, Julia, Machado, Daniela, Cartet, Gaëlle, Traversier, Aurelien, Julien, Thomas, Lina, Bruno, Bourdon, Jean-Christophe, Rosa-Calatrava, Manuel, Terrier, Olivier
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5829072/
https://ncbi.nlm.nih.gov/pubmed/29487367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-22139-6
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