5-Azacytidine prevents relapse and produces long-term complete remissions in leukemia xenografts treated with Moxetumomab pasudotox

Moxetumomab pasudotox (Moxe) is a chimeric protein composed of an anti-CD22 Fv fused to a portion of Pseudomonas exotoxin A and kills CD22-expressing leukemia cells. It is very active in hairy-cell leukemia, but many children with relapsed/refractory acute lymphoblastic leukemia (ALL) either respond...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Müller, Fabian, Cunningham, Tyler, Stookey, Stephanie, Tai, Chin-Hsien, Burkett, Sandra, Jailwala, Parthav, Stetler Stevenson, Maryalice, Cam, Margaret C., Wayne, Alan S., Pastan, Ira
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828592/
https://ncbi.nlm.nih.gov/pubmed/29432154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1714512115
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