A miRNA181a/NFAT5 axis links impaired T cell tolerance induction with autoimmune type 1 diabetes

Molecular checkpoints that trigger the onset of islet autoimmunity or progression to human type 1 diabetes (T1D) are incompletely understood. Using T cells from children at an early stage of islet autoimmunity without clinical T1D, we find that a microRNA181a (miRNA181a)–mediated increase in signal...

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Publicado no:Sci Transl Med
Main Authors: Serr, Isabelle, Scherm, Martin G., Zahm, Adam M., Schug, Jonathan, Flynn, Victoria K., Hippich, Markus, Kälin, Stefanie, Becker, Maike, Achenbach, Peter, Nikolaev, Alexei, Gerlach, Katharina, Liebsch, Nicole, Loretz, Brigitta, Lehr, Claus-Michael, Kirchner, Benedikt, Spornraft, Melanie, Haase, Bettina, Segars, James, Küper, Christoph, Palmisano, Ralf, Waisman, Ari, Willis, Richard A., Kim, Wan-Uk, Weigmann, Benno, Kaestner, Klaus H., Ziegler, Anette-Gabriele, Daniel, Carolin
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828501/
https://ncbi.nlm.nih.gov/pubmed/29298866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aag1782
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