Autoimmune reactivity to malondialdehyde adducts in systemic lupus erythematosus is associated with disease activity and nephritis

BACKGROUND: Immunoglobulin M (IgM) autoreactivity to malondialdehyde (MDA) protein modifications is part of the natural antibody repertoire in health and may have beneficial functions. In contrast, IgG anti-MDA are increased in chronic inflammation and autoimmunity and may instead have pathogenic pr...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Hardt, Uta, Larsson, Anders, Gunnarsson, Iva, Clancy, Robert M., Petri, Michelle, Buyon, Jill P., Silverman, Gregg J., Svenungsson, Elisabet, Grönwall, Caroline
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5827973/
https://ncbi.nlm.nih.gov/pubmed/29482604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-018-1530-2
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