DACHPt-Loaded Nanoparticles Self-assembled from Biodegradable Dendritic Copolymer Polyglutamic Acid-b-D-α-Tocopheryl Polyethylene Glycol 1000 Succinate for Multidrug Resistant Lung Cancer Therapy

The clinical applications of platinum-based antitumor agents are still largely limited by severe side effects as well as multidrug resistance (MDR). To solve these problems, we developed an 1,2-diaminocyclohexane-platinum(II) (DACHPt)-loaded nanoparticle (NP-TPGS-Pt) by self-assembly of poly(amidoam...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Tsai, Hsiang-I, Jiang, Lijuan, Zeng, Xiaowei, Chen, Hongbo, Li, Zihuang, Cheng, Wei, Zhang, Jinxie, Pan, Jie, Wan, Dong, Gao, Li, Xie, Zhenhua, Huang, Laiqiang, Mei, Lin, Liu, Gan
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5826327/
https://ncbi.nlm.nih.gov/pubmed/29515445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00119
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