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Runx1 is sufficient for blood cell formation from non-hemogenic endothelial cells in vivo only during early embryogenesis

Hematopoietic cells differentiate during embryogenesis from a population of endothelial cells called hemogenic endothelium (HE) in a process called the endothelial-to-hematopoietic transition (EHT). The transcription factor Runx1 is required for EHT, but for how long and which endothelial cells are...

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Pubblicato in:Development
Autori principali: Yzaguirre, Amanda D., Howell, Elizabeth D., Li, Yan, Liu, Zijing, Speck, Nancy A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Company of Biologists Ltd 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5825840/
https://ncbi.nlm.nih.gov/pubmed/29361566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.158162
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