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Biopolymer Molecular Weight Can Modulate the Wound Healing Efficacy of Multivalent Sonic Hedgehog-Hyaluronic Acid Conjugates

There is a clinical need for new therapeutics to improve healing of chronic impaired wounds. Thus, we investigated how biopolymer conjugation could be used to improve the wound healing performance of a key growth factor for tissue regeneration: Sonic hedgehog (Shh). We generated two multivalent Shh...

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Detalhes bibliográficos
Publicado no:Biomacromolecules
Main Authors: Holstlaw, Taylor A., Mahomed, Mavish, Brier, Livia W., Young, David M., Boudreau, Nancy J., Jackson, Wesley M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5825181/
https://ncbi.nlm.nih.gov/pubmed/28679037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biomac.7b00553
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