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Heritable tumor cell division rate heterogeneity induces clonal dominance

Tumors consist of a hierarchical population of cells that differ in their phenotype and genotype. This hierarchical organization of cells means that a few clones (i.e., cells and several generations of offspring) are abundant while most are rare, which is called clonal dominance. Such dominance also...

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Detalles Bibliográficos
Publicado en:PLoS Comput Biol
Autores principales: Palm, Margriet M., Elemans, Marjet, Beltman, Joost B.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5825147/
https://ncbi.nlm.nih.gov/pubmed/29432417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005954
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