Claudin-18–mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis

Claudins, the integral tight junction (TJ) proteins that regulate paracellular permeability and cell polarity, are frequently dysregulated in cancer; however, their role in neoplastic progression is unclear. Here, we demonstrated that knockout of Cldn18, a claudin family member highly expressed in l...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Zhou, Beiyun, Flodby, Per, Luo, Jiao, Castillo, Dan R., Liu, Yixin, Yu, Fa-Xing, McConnell, Alicia, Varghese, Bino, Li, Guanglei, Chimge, Nyam-Osor, Sunohara, Mitsuhiro, Koss, Michael N., Elatre, Wafaa, Conti, Peter, Liebler, Janice M., Yang, Chenchen, Marconett, Crystal N., Laird-Offringa, Ite A., Minoo, Parviz, Guan, Kunliang, Stripp, Barry R., Crandall, Edward D., Borok, Zea
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5824875/
https://ncbi.nlm.nih.gov/pubmed/29400695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI90429
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