Co-occurring expression and methylation QTLs allow detection of common causal variants and shared biological mechanisms

Inherited genetic variation affects local gene expression and DNA methylation in humans. Most expression quantitative trait loci (cis-eQTLs) occur at the same genomic location as a methylation QTL (cis-meQTL), suggesting a common causal variant and shared mechanism. Using DNA and RNA from peripheral...

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Publicat a:Nat Commun
Autors principals: Pierce, Brandon L., Tong, Lin, Argos, Maria, Demanelis, Kathryn, Jasmine, Farzana, Rakibuz-Zaman, Muhammad, Sarwar, Golam, Islam, Md. Tariqul, Shahriar, Hasan, Islam, Tariqul, Rahman, Mahfuzar, Yunus, Md., Kibriya, Muhammad G., Chen, Lin S., Ahsan, Habibul
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5824840/
https://ncbi.nlm.nih.gov/pubmed/29476079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03209-9
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