Co-occurring expression and methylation QTLs allow detection of common causal variants and shared biological mechanisms

Inherited genetic variation affects local gene expression and DNA methylation in humans. Most expression quantitative trait loci (cis-eQTLs) occur at the same genomic location as a methylation QTL (cis-meQTL), suggesting a common causal variant and shared mechanism. Using DNA and RNA from peripheral...

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書誌詳細
出版年:Nat Commun
主要な著者: Pierce, Brandon L., Tong, Lin, Argos, Maria, Demanelis, Kathryn, Jasmine, Farzana, Rakibuz-Zaman, Muhammad, Sarwar, Golam, Islam, Md. Tariqul, Shahriar, Hasan, Islam, Tariqul, Rahman, Mahfuzar, Yunus, Md., Kibriya, Muhammad G., Chen, Lin S., Ahsan, Habibul
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2018
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5824840/
https://ncbi.nlm.nih.gov/pubmed/29476079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03209-9
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