Interpretability of Cancer Clinical Trial Results Using Restricted Mean Survival Time as an Alternative to the Hazard Ratio

IMPORTANCE: In a comparative clinical study with progression-free survival (PFS) or overall survival (OS) as the end point, the hazard ratio (HR) is routinely used to design the study and to estimate the treatment effect at the end of the study. The clinical interpretation of the HR may not be strai...

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Vydáno v:JAMA Oncol
Hlavní autoři: Pak, Kyongsun, Uno, Hajime, Kim, Dae Hyun, Tian, Lu, Kane, Robert C., Takeuchi, Masahiro, Fu, Haoda, Claggett, Brian, Wei, Lee-Jen
Médium: Artigo
Jazyk:Inglês
Vydáno: American Medical Association 2017
Témata:
Original Investigation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5824272/
https://ncbi.nlm.nih.gov/pubmed/28975263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2017.2797
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