Interpretability of Cancer Clinical Trial Results Using Restricted Mean Survival Time as an Alternative to the Hazard Ratio

IMPORTANCE: In a comparative clinical study with progression-free survival (PFS) or overall survival (OS) as the end point, the hazard ratio (HR) is routinely used to design the study and to estimate the treatment effect at the end of the study. The clinical interpretation of the HR may not be strai...

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Udgivet i:JAMA Oncol
Main Authors: Pak, Kyongsun, Uno, Hajime, Kim, Dae Hyun, Tian, Lu, Kane, Robert C., Takeuchi, Masahiro, Fu, Haoda, Claggett, Brian, Wei, Lee-Jen
Format: Artigo
Sprog:Inglês
Udgivet: American Medical Association 2017
Fag:
Original Investigation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5824272/
https://ncbi.nlm.nih.gov/pubmed/28975263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2017.2797
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