Effect of Fluorouracil, Leucovorin, and Oxaliplatin With or Without Onartuzumab in HER2-Negative, MET-Positive Gastroesophageal Adenocarcinoma: The METGastric Randomized Clinical Trial

IMPORTANCE: Dysregulation of the mesenchymal-epithelial transition (MET) signaling pathway is associated with poor prognosis in gastroesophageal adenocarcinoma (GEC). We report results of METGastric, a phase 3 trial of the MET inhibitor onartuzumab plus standard first-line chemotherapy for human epi...

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Vydáno v:JAMA Oncol
Hlavní autoři: Shah, Manish A., Bang, Yung-Jue, Lordick, Florian, Alsina, Maria, Chen, Meng, Hack, Stephen P., Bruey, Jean Marie, Smith, Dustin, McCaffery, Ian, Shames, David S., Phan, See, Cunningham, David
Médium: Artigo
Jazyk:Inglês
Vydáno: American Medical Association 2016
Témata:
Original Investigation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5824210/
https://ncbi.nlm.nih.gov/pubmed/27918764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2016.5580
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