Increased HIV-1 transcriptional activity and infectious burden in peripheral blood and gut-associated CD4(+) T cells expressing CD30

HIV-1-infected cells persist indefinitely despite the use of combination antiretroviral therapy (ART), and novel therapeutic strategies to target and purge residual infected cells in individuals on ART are urgently needed. Here, we demonstrate that CD4(+) T cell-associated HIV-1 RNA is often highly...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Hogan, Louise E., Vasquez, Joshua, Hobbs, Kristen S., Hanhauser, Emily, Aguilar-Rodriguez, Brandon, Hussien, Rajaa, Thanh, Cassandra, Gibson, Erica A., Carvidi, Alexander B., Smith, Louis C. B., Khan, Shahzada, Trapecar, Martin, Sanjabi, Shomyseh, Somsouk, Ma, Stoddart, Cheryl A., Kuritzkes, Daniel R., Deeks, Steven G., Henrich, Timothy J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5823470/
https://ncbi.nlm.nih.gov/pubmed/29470552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006856
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