Intraocular DHODH-inhibitor PP-001 suppresses relapsing experimental uveitis and cytokine production of human lymphocytes, but not of RPE cells

BACKGROUND: Uveitis is a potentially blinding inflammatory disease of the inner eye with a high unmet need for new therapeutic interventions. Here, we wanted to investigate the suppressive effect of the intraocular application of the small molecule dihydroorotate dehydrogenase (DHODH)-inhibitor PP-0...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Diedrichs-Möhring, Maria, Niesik, Sandy, Priglinger, Claudia S., Thurau, Stephan R., Obermayr, Franz, Sperl, Stefan, Wildner, Gerhild
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5822610/
https://ncbi.nlm.nih.gov/pubmed/29467002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-018-1088-6
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