Red Blood Cells Homeostatically Bind Mitochondrial DNA through TLR9 to Maintain Quiescence and to Prevent Lung Injury

Rationale: Potentially hazardous CpG-containing cell-free mitochondrial DNA (cf-mtDNA) is routinely released into the circulation and is associated with morbidity and mortality in critically ill patients. How the body avoids inappropriate innate immune activation by cf-mtDNA remains unknown. Because...

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Udgivet i:Am J Respir Crit Care Med
Main Authors: Hotz, Meghan J., Qing, Danielle, Shashaty, Michael G. S., Zhang, Peggy, Faust, Hilary, Sondheimer, Neal, Rivella, Stefano, Worthen, G. Scott, Mangalmurti, Nilam S.
Format: Artigo
Sprog:Inglês
Udgivet: American Thoracic Society 2018
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5821907/
https://ncbi.nlm.nih.gov/pubmed/29053005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201706-1161OC
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