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Vinculin forms a directionally asymmetric catch bond with F-actin
Vinculin is an actin-binding protein thought to reinforce cell-cell and cell-matrix adhesions. However, how mechanical load affects the vinculin/F-actin bond is unclear. Using a single-molecule optical trap assay, we found that vinculin forms a force-dependent catch bond with F-actin via its tail do...
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| Udgivet i: | Science |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5821505/ https://ncbi.nlm.nih.gov/pubmed/28818948 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aan2556 |
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