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Genetic compensation triggered by actin mutation prevents the muscle damage caused by loss of actin protein

The lack of a mutant phenotype in homozygous mutant individuals’ due to compensatory gene expression triggered upstream of protein function has been identified as genetic compensation. Whilst this intriguing process has been recognized in zebrafish, the presence of homozygous loss of function mutati...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Sztal, Tamar E., McKaige, Emily A., Williams, Caitlin, Ruparelia, Avnika A., Bryson-Richardson, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5821405/
https://ncbi.nlm.nih.gov/pubmed/29420541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007212
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