Angiotensin 1-7 Overexpression Mediated by a Capsid-optimized AAV8 Vector Leads to Significant Growth Inhibition of Hepatocellular Carcinoma In vivo

Background: Angiotensin-(1-7) [Ang-(1-7)] has been identified to inhibit the growth of many types of tumor cells both in vitro and in vivo. However, the rapid degradation of Ang-(1-7) in vivo limits its clinical application. Adeno-associated virus (AAV) serotype-8 is a remarkable vector for long-ter...

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Detalhes bibliográficos
Publicado no:Int J Biol Sci
Main Authors: Mao, Yingying, Pei, Nana, Chen, Xinglu, Chen, Huiying, Yan, Renhe, Bai, Na, Li, Andrew, Li, Jinlong, Zhang, Yanling, Du, Hongyan, Chen, Baihong, Sumners, Colin, Wang, Xuejun, Wang, Shengqi, Li, Hongwei
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5821049/
https://ncbi.nlm.nih.gov/pubmed/29483825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.22235
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