LEARNING AND AGE-RELATED CHANGES IN GENOME-WIDE H2A.Z BINDING IN THE MOUSE HIPPOCAMPUS

Histone variants were recently discovered to regulate neural plasticity, with H2A.Z emerging as a memory suppressor. Using whole-genome sequencing of the mouse hippocampus, we show that basal H2A.Z occupancy is positively associated with steady-state transcription, whereas learning-induced H2A.Z rem...

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Détails bibliographiques
Publié dans:Cell Rep
Auteurs principaux: Stefanelli, Gilda, Azam, Amber B., Walters, Brandon J., Brimble, Mark A., Gettens, Caroline P., Bouchard-Cannon, Pascale, Cheng, Hai-Ying M., Davidoff, Andrew M., Narkaj, Klotilda, Day, Jeremy J., Kennedy, Andrew J., Zovkic, Iva B.
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5820781/
https://ncbi.nlm.nih.gov/pubmed/29386101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.01.020
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