CYP2C19 variant mitigates Alzheimer disease pathophysiology in vivo and postmortem

OBJECTIVE: To verify whether CYP polymorphisms are associated with amyloid-β (Aβ) pathology across the spectrum of clinical Alzheimer disease using in vivo and postmortem data from 2 independent cohorts. METHODS: A candidate-gene approach tested the association between 5 genes (28 single nucleotide...

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Bibliografiset tiedot
Julkaisussa:Neurol Genet
Päätekijät: Benedet, Andréa L., Yu, Lei, Labbe, Aurélie, Mathotaarachchi, Sulantha, Pascoal, Tharick A., Shin, Monica, Kang, Min-Su, Gauthier, Serge, Rouleau, Guy A., Poirier, Judes, Bennett, David A., Rosa-Neto, Pedro
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Wolters Kluwer 2018
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5820598/
https://ncbi.nlm.nih.gov/pubmed/29473050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/NXG.0000000000000216
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