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Evaluation of Treatment Effect with Paired Failure Times in a Single-Arm Phase II Trial in Oncology

In early phase clinical trials of cytotoxic drugs in oncology, the efficacy is typically evaluated based on the tumor shrinkage. However, this criterion is not always appropriate for more recent cytostatic agents, and alternative endpoints have been proposed. The growth modulation index (GMI), defin...

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Detalhes bibliográficos
Publicado no:Comput Math Methods Med
Main Authors: Texier, Matthieu, Rotolo, Federico, Ducreux, Michel, Bouché, Olivier, Pignon, Jean-Pierre, Michiels, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5820554/
https://ncbi.nlm.nih.gov/pubmed/29568321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/1672176
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