CD38 promotes pristane-induced chronic inflammation and increases susceptibility to experimental lupus by an apoptosis-driven and TRPM2-dependent mechanism

In this study, we investigated the role of CD38 in a pristane-induced murine model of lupus. CD38-deficient (Cd38(−/−)) but not ART2-deficient (Art2(−/−)) mice developed less severe lupus compared to wild type (WT) mice, and their protective phenotype consisted of (i) decreased IFN-I-stimulated gene...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: García-Rodríguez, Sonia, Rosal-Vela, Antonio, Botta, Davide, Cumba Garcia, Luz M., Zumaquero, Esther, Prados-Maniviesa, Verónica, Cerezo-Wallis, Daniela, Lo Buono, Nicola, Robles-Guirado, José-Ángel, Guerrero, Salvador, González-Paredes, Elena, Andrés-León, Eduardo, Corbí, Ángel, Mack, Matthias, Koch-Nolte, Friedrich, Merino, Ramón, Zubiaur, Mercedes, Lund, Frances E., Sancho, Jaime
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5820326/
https://ncbi.nlm.nih.gov/pubmed/29463868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-21337-6
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