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What makes it difficult to refine protein models further via molecular dynamics simulations?

Protein structure refinement remains a challenging yet important problem as it has the potential to bring already accurate template-based models to near-native resolution. Refinement based on molecular dynamics simulations has been a highly promising approach and the performance of MD-based refineme...

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Detalhes bibliográficos
Publicado no:Proteins
Main Authors: Heo, Lim, Feig, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5820117/
https://ncbi.nlm.nih.gov/pubmed/28975670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.25393
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