Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP

The angiopoietin (ANGPT)–TIE2/TEK signaling pathway is essential for blood and lymphatic vascular homeostasis. ANGPT1 is a potent TIE2 activator, whereas ANGPT2 functions as a context-dependent agonist/antagonist. In disease, ANGPT2-mediated inhibition of TIE2 in blood vessels is linked to vascular...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Souma, Tomokazu, Thomson, Benjamin R., Heinen, Stefan, Anna Carota, Isabel, Yamaguchi, Shinji, Onay, Tuncer, Liu, Pan, Ghosh, Asish K., Li, Chengjin, Eremina, Vera, Hong, Young-Kwon, Economides, Aris N., Vestweber, Dietmar, Peters, Kevin G., Jin, Jing, Quaggin, Susan E.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2018
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5819405/
https://ncbi.nlm.nih.gov/pubmed/29358379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1714446115
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