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Chaperone substrate provides missing link for cancer drug discovery
Both Hsp70 and Hsp90 chaperones are overexpressed in cancer, making them relevant targets for the development of cancer chemotherapeutics, but a lack of biomolecular readouts for Hsp70 inhibition has limited the pursuit of specific inhibitors for this enzyme. A new study from Cesa et al. identifies...
Guardat en:
| Publicat a: | J Biol Chem |
|---|---|
| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5818199/ https://ncbi.nlm.nih.gov/pubmed/29453286 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.H118.001591 |
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