Ligand-activated epidermal growth factor receptor (EGFR) signaling governs endocytic trafficking of unliganded receptor monomers by non-canonical phosphorylation

The canonical description of transmembrane receptor function is initial binding of ligand, followed by initiation of intracellular signaling and then internalization en route to degradation or recycling to the cell surface. It is known that low concentrations of extracellular ligand lead to a higher...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Tanaka, Tomohiro, Zhou, Yue, Ozawa, Tatsuhiko, Okizono, Ryuya, Banba, Ayako, Yamamura, Tomohiro, Oga, Eiji, Muraguchi, Atsushi, Sakurai, Hiroaki
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2018
Ämnen:
Signal Transduction
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5818182/
https://ncbi.nlm.nih.gov/pubmed/29255092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.811299
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