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Ligand-activated epidermal growth factor receptor (EGFR) signaling governs endocytic trafficking of unliganded receptor monomers by non-canonical phosphorylation

The canonical description of transmembrane receptor function is initial binding of ligand, followed by initiation of intracellular signaling and then internalization en route to degradation or recycling to the cell surface. It is known that low concentrations of extracellular ligand lead to a higher...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Tanaka, Tomohiro, Zhou, Yue, Ozawa, Tatsuhiko, Okizono, Ryuya, Banba, Ayako, Yamamura, Tomohiro, Oga, Eiji, Muraguchi, Atsushi, Sakurai, Hiroaki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5818182/
https://ncbi.nlm.nih.gov/pubmed/29255092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.811299
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