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The oligomerization state of bacterial enzyme I (EI) determines EI's allosteric stimulation or competitive inhibition by α-ketoglutarate

The bacterial phosphotransferase system (PTS) is a signal transduction pathway that couples phosphoryl transfer to active sugar transport across the cell membrane. The PTS is initiated by phosphorylation of enzyme I (EI) by phosphoenolpyruvate (PEP). The EI phosphorylation state determines the phosp...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Nguyen, Trang T., Ghirlando, Rodolfo, Venditti, Vincenzo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5818175/
https://ncbi.nlm.nih.gov/pubmed/29317499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001466
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