Molecular differences in IDH wildtype glioblastoma according to MGMT promoter methylation

BACKGROUND: O(6)-methylguanine-DNA-methyltransferase (MGMT) promoter methylation status is a predictive biomarker in glioblastoma. We investigated whether this marker furthermore defines a molecularly distinct tumor subtype with clinically different outcome. METHODS: We analyzed copy number variatio...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Kessler, Tobias, Sahm, Felix, Sadik, Ahmed, Stichel, Damian, Hertenstein, Anne, Reifenberger, Guido, Zacher, Angela, Sabel, Michael, Tabatabai, Ghazaleh, Steinbach, Joachim, Sure, Ulrich, Krex, Dietmar, Grosu, Anca-L, Bewerunge-Hudler, Melanie, Jones, David, Pfister, Stefan M, Weller, Michael, Opitz, Christiane, Bendszus, Martin, von Deimling, Andreas, Platten, Michael, Wick, Wolfgang
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5817966/
https://ncbi.nlm.nih.gov/pubmed/29016808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox160
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