Loss of host-derived osteopontin creates a glioblastoma-promoting microenvironment

BACKGROUND: Microglia and periphery-derived monocytes infiltrate human and mouse glioblastoma and their density is positively correlated with malignancy. Using microarray and RNA sequencing, we have previously shown that glioblastoma-associated microglia/monocytes (GAMs) express osteopontin/SPP1. ME...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Szulzewsky, Frank, Schwendinger, Nina, Güneykaya, Dilansu, Cimino, Patrick J, Hambardzumyan, Dolores, Synowitz, Michael, Holland, Eric C, Kettenmann, Helmut
Format: Artigo
Language:Inglês
Published: Oxford University Press 2018
Subjects:
Basic and Translational Investigations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5817947/
https://ncbi.nlm.nih.gov/pubmed/29016864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox165
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