miR-19b enhances proliferation and apoptosis resistance via the EGFR signaling pathway by targeting PP2A and BIM in non-small cell lung cancer

BACKGROUND: Epidermal growth factor receptor (EGFR) mutations enable constitutive active downstream signaling of PI3K/AKT, KRAS/ERK and JAK/STAT pathways, and promote tumor progression by inducing uncontrolled proliferation, evasion of apoptosis and migration of non-small cell lung cancer (NSCLC). I...

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Bibliografiske detaljer
Udgivet i:Mol Cancer
Main Authors: Baumgartner, Ulrich, Berger, Fabienne, Hashemi Gheinani, Ali, Burgener, Sabrina Sofia, Monastyrskaya, Katia, Vassella, Erik
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5817797/
https://ncbi.nlm.nih.gov/pubmed/29455644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-018-0781-5
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